Table 4.
Meta-analysis results for SBP stratified by PPARGC1A Gly482Ser genotypes
| Cohort | SBP, mmHg |
ANOVA, P Value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype Frequencies |
Gly/Gly | Gly/Ser | Ser/Ser | Significance of Interaction | |||||||||
| Gly/Gly | Gly/Ser | Ser/Ser | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Gene-Sex | Gene-Age | Gene-BMI | ||
| Danish whites | |||||||||||||
| Study 1 (Ref. 8)*† | 454 | 442 | 117 | 133.9 | 132.3–135.5 | 133.3 | 131.7–134.9 | 129.6 | 126.5–132.7 | 0.055 | 0.189 | 0.571 | 0.891 |
| Study 3 (Ref. 8)*† | 63 | 69 | 25 | 136.2 | 131.6–140.8 | 131.6 | 127.2–136 | 139.8 | 132.4–147.2 | 0.131 | 0.116 | 0.477 | 0.581 |
| Study 4 (Ref. 8)*† | 281 | 316 | 101 | 157.5 | 154.9–160.1 | 160.0 | 157.6–162.4 | 154.9 | 150.6–159.2 | 0.101 | 0.106 | 0.988 | 0.574 |
| Study 5 (Ref. 8)*† | 212 | 195 | 65 | 135.0 | 132.6–137.4 | 133.7 | 131.2–136.2 | 134.8 | 130.5–139.1 | 0.748 | 0.653 | 0.305 | 0.113 |
| Pima Indians† | 735 | 318 | 35 | 115.8 | 114.6–117 | 116.8 | 114.9–118.7 | 121.6 | 116–127.2 | 0.103 | 0.082 | 0.901 | 0.036 |
| UK whites | |||||||||||||
| MRC Ely† | 233 | 306 | 73 | 127.6 | 125.7–129.5 | 125.2 | 123.5–126.9 | 121.2 | 117.8–124.6 | 0.005 | 0.203 | 0.123 | 0.632 |
| CCCS cases† | 175 | 176 | 43 | 138.4 | 135.9–140.9 | 137.4 | 134.9–139.9 | 141.4 | 136.3–146.5 | 0.197 | 0.031 | 0.336 | 0.439 |
| CCCS controls† | 194 | 197 | 75 | 145.5 | 143.1–147.9 | 143.7 | 141.3–146.1 | 143.8 | 140–147.6 | 0.484 | 0.147 | 0.292 | 0.791 |
| French Canadians (Ref. 2)† | 64 | 73 | 19 | 142.0 | 137.4–146.6 | 144.6 | 140.3–148.9 | 137.8 | 129.4–146.2 | 0.131 | 0.625 | 0.173 | 0.031 |
| EPIC | |||||||||||||
| Obese† | 364 | 339 | 96 | 138.8 | 137.2–140.4 | 141.0 | 139.3–142.7 | 139.1 | 135.9–142.3 | 0.183 | 0.043 | 0.015 | 0.695 |
| Cohort† | 762 | 789 | 201 | 134.1 | 133–135.2 | 134.0 | 132.9–135.1 | 134.4 | 132.2–136.6 | 0.947 | 0.804 | 0.556 | 0.654 |
| Danish whites (Ref. 4)‡ | 931 | 1,036 | 288 | 128.4 | 127.2–129.6 | 129.6 | 128.4–130.8 | 129.5 | 127.1–131.9 | 0.09 | |||
| Asian Indians | |||||||||||||
| Controls (Ref. 3)‡ | 534 | 360 | 81 | 120.0 | 118.6–121.4 | 121.0 | 119.2–122.8 | 119.0 | 115.7–122.3 | 0.42 | |||
| Cases (Ref. 3)‡ | 303 | 212 | 52 | 130.0 | 127.9–132.1 | 126.0 | 123.8–128.2 | 124.0 | 119.7–128.3 | 0.006 | |||
| Slovenian whites | |||||||||||||
| Cases (Ref. 5)‡ | 114 | 118 | 29 | 144.6 | 140.5–148.7 | 146.5 | 142.5–150.5 | 141.0 | 132.8–149.2 | 0.45 | |||
| Controls (Ref. 5)‡ | 14 | 15 | 1 | 143.8 | 133.1–154.5 | 145.2 | 133.1–157.3 | 142.0 | 0.6 | ||||
| Overall | 5,433 | 4,961 | 1,301 | 131.0 | 130.5–131.5 | 133.1 | 132.6–133.6 | 133.5 | 132.5–134.5 | 0.409§ | 0.966 | 0.026 | 0.202 |
| Standard error | 0.006§ | ||||||||||||
| Cohort heterogeneity P | 0.003§ | ||||||||||||
| Ethnicity heterogeneity P | 0.649§ | ||||||||||||
| Caucasian only | |||||||||||||
| Overall | 3,861 | 4,071 | 1,133 | 135.6 | 135.0–136.1 | 135.8 | 135.2–136.3 | 135.3 | 134.2–136.4 | 0.419§ | 0.960 | 0.804 | 0.138 |
| Heterogeneity P | 0.035§ | ||||||||||||
*
Studies 1, 3, 4, and 5 correspond to the study numbers mentioned in the paper.
†
Studies with raw data. The main effect and interaction analyses are adjusted for age and sex.
‡
Studies from published paper. Mean, SD, and ANOVA P values were obtained from published papers or from authors.
§
Based on 10,000 simulations. A random-effect generalized linear model is applied if P < 0.05 for heterogeneity; otherwise, a fixed model is applied.