Fig. 2.

Bronchoalveolar lavage neutrophils (A), keratinocyte-derived chemokines (KC) (B), macrophage inflammatory protein 2 (MIP-2) (C), LPS-induced C-X-C chemokine (LIX) (D), interferon-inducible protein 10 (IP-10) (E), and monocyte chemoattractant protein 1 (MCP-1) (F) in WT and db/db mice exposed to O₃ (2 parts per million for 3 h). Mice were studied 4 h after cessation of O₃ exposure and were treated by gavage with either water or metformin every day for 2 wk before exposure. Results are means ± SE of data from 5–6 mice per group. *P < 0.05 vs. WT mice with the same drug treatment.