Table 2.
Average episode numbers and durations of W, NREMS, and REMS on the baseline day and on days after virus infection in WT and TNF-2R KO mice
| Baseline | Virus 1 | Virus 2 | Virus 4 | Virus 8 | |
|---|---|---|---|---|---|
| Sleep episode numbers | |||||
| W | |||||
| WT | 6.38±0.33 | 5.83±0.40 | 6.17±0.42 | 8.34±0.98* | 8.15±0.76 |
| KO | 5.49±0.34 | 5.44±0.41 | 6.64±0.71* | 8.03±0.89* | 10.46±1.45* |
| NREMS | |||||
| WT | 11.19±0.70 | 10.49±0.44 | 12.41±0.98 | 14.55±1.23* | 15.64±0.83* |
| KO | 10.79±0.79 | 10.82±0.57 | 13.17±1.20* | 15.01±1.33* | 16.31±1.17* |
| REMS | |||||
| WT | 2.32±0.18 | 2.27±0.20 | 2.52±0.22 | 2.05±0.22 | 2.06±0.25 |
| KO | 2.50±0.15 | 2.61±0.21 | 2.86±0.19* | 2.36±0.18 | 1.63±0.20* |
| Sleep episode durations | |||||
| W | |||||
| WT | 5.16±0.36 | 6.45±0.69 | 5.19±0.67 | 4.67±0.92 | 3.28±0.33 |
| KO | 7.82±0.65† | 7.85±1.02 | 5.84±1.12* | 4.45±0.74* | 3.97±1.76* |
| NREMS | |||||
| WT | 3.17±0.17 | 3.29±0.15 | 3.01±0.15 | 2.60±0.21* | 2.52±0.14* |
| KO | 2.91±0.23 | 2.88±0.21 | 2.58±0.26* | 2.49±0.28* | 2.37±0.25* |
| REMS | |||||
| WT | 1.41±0.06 | 1.49±0.05 | 1.37±0.07 | 1.35±0.09 | 1.35±0.11 |
| KO | 1.48±0.04 | 1.55±0.05 | 1.49±0.03 | 1.49±0.03 | 1.72±0.07* |
Values are means ± SE. Sleep episode numbers are hourly average numbers, and sleep episode durations are average durations during the entire 24-h recording periods. Postchallenge days: virus 1 and virus 2, asymptomatic infection prodrome on days 1 and 2; virus 4, acute phase of infection on day 4; virus 8, early recovery phase of infection on day 8.
*
Significant difference from baseline;
†
significant difference between wild-type (WT) and TNF-α double-receptor (TNF-2R) knockout (KO) (univariate tests of significance for planned comparisons, P < 0.05).