Table 1.
Somatic action potential characteristics of myelinated A-type and Ah-type and unmyelinated C-type aortic baroreceptor neurons (ABN) and vagal neurons (VGN)
|
Female ABN, n = 64 |
Male ABN, n = 44
|
|||||
|---|---|---|---|---|---|---|
| Action Potential Measures | A-Type | Ah-Type | C-Type | A-Type | Ah-Type | C-Type |
| RMP | −63.6±1.7 | −63.0±1.0 | −63.8±2.2 | −62.7±1.5 | −63 | −62.6±3 |
| APFT | −44.6±1.7 | −37.0±3.9†§ | −25.3±2.8 | −44.4±3.1 | −34.1 | −27.3±2.1 |
| APPeak | 49.0±3.1 | 55.5±3.4 | 50.1±3.5 | 50.6±2.13 | 54.9 | 51.1±5.7 |
| APD | 0.84±0.2 | 1.99±0.1†§ | 2.96±0.5 | 0.80±0.22 | 2.06 | 2.92±0.6 |
| AHPPeak | −66.9±1 | −66.6±1.2 | −64.4±1.2 | −67.4±1.9 | −65.7 | −65.6±1.4 |
| AHP80 | 20.4±10.7 | 104±3† | 93.0±27 | 12.4±2.2 | 103.02 | 82.6±24.3 |
| UVAPD50 | 202±9 | 129±9†§ | 40.1±13.4 | 243±78 | 171.7 | 90.4±25.8 |
| DVAPD50 | −138±10 | −46.6±9.4†‡ | −33.6±10.3 | −162±51 | −36.8 | −26.0±8.2 |
| N, % | 10 (15.62) | 7 (10.94) | 47 (73.43) | 7(15.9) | 1 (2.27) | 36 (81.8) |
| ΔE-mATP + | 10 | 7 | 7 | 1 | ||
| CAP+ | 45 | 34 | ||||
| + To both | 2 | 1 | ||||
| − To both | 1 | |||||
|
Female VGN, n = 90 |
Male VGN, n = 79
|
|||||
|---|---|---|---|---|---|---|
| A-Type | Ah-Type | C-Type | A-Type | Ah-Type | C-Type | |
| RMP | −63.1±2.8 | −64.1±2.8 | −62.9±3.1 | −64.6±3.4 | −63.7±2.1 | −63.1±3 |
| APFT | −43.3±2.4 | −36.6±3.9†§ | −26.1±4.1 | −43.9±2.2 | −37.3±3.4*‡ | −26.7±3.8 |
| APPeak | 48.1±4 | 52.3±5 | 47.0±5 | 49.5±3.5 | 50.2±8 | 46.7±3.9 |
| APD | 0.82±0.2 | 1.89±0.6†§ | 2.48±0.7 | 0.93±0.3 | 1.84±0.1†‡ | 2.29±0.4 |
| AHPPeak | −66.1±1.8 | −67.5±2.2 | −68.3±2.5 | −66.8±2.1 | −68.9±1.4 | −68.6±2.5 |
| AHP80 | 19.9±12.5 | 63.8±32.6† | 78.3±33.5 | 32.5±20.6 | 103±49.6† | 80.1±38.6 |
| UVAPD50 | 189±69 | 111±22†§ | 40.9±14.2 | 207±21 | 119±28†§ | 39.3±13.8 |
| DVAPD50 | −136±49 | −54.2±11.9†‡ | −41.8±16.5 | −103±20 | −53.6±17.3† | −46.9±10.6 |
| N (%) | 14 (15.55) | 16 (17.78) | 60 (66.67) | 14 (17.72) | 3 (3.79) | 62 (78.49) |
| ΔE-mATP(+) | 14 | 14 | 1 | 14 | 1 | |
| CAP+ | 56 | 1 | 59 | |||
| + To both | 1 | 1 | 2 | |||
| − To both | 1 | 2 | 1 | 1 | ||
Data are means ± SD. Inward currents were positive (+) or negative (−) elicited by 10 μM αβ-mATP or 100 nM capsaicin (CAP). RMP, resting membrane potential; APFT, action potential firing threshold; APPeak, action potential peak; APD50, AP duration at 50% deflection; AHPPeak, peak after hyperpolarization; AHP80, time for recovery to within 80% of RMP from AHPPeak; UVAPD50, upstroke velocity as measured at APD50; DVAPD50, downstroke velocity as measured at APD50.
*
P < 0.05,
†
P < 0.01 for A-type vs. Ah-type; and
‡
P < 0.05,
§
P < 0.01 for Ah-type vs. C-type.