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PDE2 inhibition blocks cGMP-induced decrease in net Cl absorption by isolated, perfused THALs. A: cumulative data showing the effect of db-cGMP (500 μM) on THAL net Cl absorption (n = 6, *P < 0.05). B: cumulative data showing the effect of db-cGMP (500 μM) on THAL net Cl absorption in tubules preincubated with the PDE2 inhibitor BAY 60-7550 (100 nM) (n = 6). Addition of the PDE2 inhibitor alone to the bath did not affect net Cl absorption (see results).
