Fig. 7.

Effects of oleic acid (OA) on renal dysfunction in mice subjected to I/R. Shown are plasma BUN (A) and Cr (B) in sham veh, I/R veh, and I/R OA mice. Male 3-mo-old B6129SF2/J mice were subjected to bilateral renal ischemia for 30 min by clamping of the renal artery, followed by reperfusion. One hour after the ischemia, vehicle (I/R veh) or OA (I/R OA) was administered at 500 μg/kg every 6 h via intraperitoneal injection. Of note, the sham veh and I/R veh mice in these experiments were separate from those described in Fig. 1. Twenty-four hours after I/R, the animals were killed for evaluation of renal injury. Values are means ± SE; n = 5/group.