Figure 1.

Dose-response curves of the percentage of convulsing mice vs single doses of intraperitoneal bupropion HCl, erythrohydrobupropion HCl, threohydrobupropion HCl and hydroxybupropion HCl 25, 50 and 75 mg/kg in Swiss albino mice. Probit analysis revealed the dose-response curves were statistically significantly different (p < 0.0001) and the CD₅₀ values were 82, 61, 50 and 35 mg/kg for the bupropion HCl, erythrohydrobupropion HCl, threohydrobupropion HCl and hydroxybupropion HCl treatments, respectively. The actual doses of the three metabolites administered to mice were equimolar equivalents of the doses of bupropion HCl 25, 50 and 75 mg/kg. HCl = hydrochloride.