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Mean ± SD convulsions per mouse following the intraperitoneal administration of bupropion HCl and bupropion metabolites
| Dose* (mg/kg) | Bupropion HCl | Erythrohydrobupropion HCl | Threohydrobupropion HCl | Hydroxybupropion HCl |
| 25 | 0 | 0 | 0 | 0 |
| 50 | 0 | 0.1 ± 0.3 | 7.0 ± 10.0 | 11.0 ± 10.3 |
| 75 | 0.5 ± 1.6 | 5.5 ± 6.2 | 21.2 ± 14.8 | 147.5 ± 106.0 |
*10 mice per dose per treatment.
