Table 5.
Mean ± SD number of mild, moderate and severe convulsions following the intraperitoneal administration of bupropion HCl and bupropion metabolites
| Dose* (mg/kg) | Bupropion HCl | Erythrohydrobupropion HCl | Threohydrobupropion HCl | Hydroxybupropion HCl | ||||||||
| Mild | Moderate | Severe | Mild | Moderate | Severe | Mild | Moderate | Severe | Mild | Moderate | Severe | |
| 25 | - | - | - | - | - | - | - | - | - | - | - | - |
| 50 | - | - | - | - | 0.1 ± 0.3 | - | 5.4 ± 8.9 | 1.3 ± 1.5 | 0.3 ± 0.7 | 7.0 ± 7.5 | 2.4 ± 2.3 | 1.6 ± 3.7 |
| 75 | 0.5 ± 1.6 | - | - | 3.4 ± 5.4 | 1.8 ± 2.0 | 0.3 ± 0.5 | 10.8 ± 7.5 | 5.7 ± 5.5 | 4.7 ± 6.1 | 113.3 ± 110.1 | 20.7 ± 20.2 | 13.3 ± 17.8 |
*10 mice per dose per treatment.
- Indicates no convulsions.