Table 1.

Anti-inflammatory activity data of curcumin derivatives

Compound	R1	R2	R3	R4	ED50 (mg/kg)
2	H	OCH3	OH	H	38 ± 4
3	H	H	OH	H	73 ± 5
12	H	H	H	H	NA
13	H	OCH3	H	H	NA
14	H	OCH3	OCH3	OCH3	NA
15	H	CH3	OH	CH3	13 ± 2
16	H	C2H5	OH	C2H5	22 ± 6
17	H	i-C3H7	OH	i-C3H7	58 ± 21
18	OCH3	H	H	H	NA
19	H	H	Cl	H	NA
20	H	H	OCH3	H	82 ± 7
21	H	H	CH3	H	80 ± 18
22	H	OCH3	OCH3	H	50 ± 22
23	H	t-C4H9	OH	t-C4H9	NA
24	H	OCH3	OH	OCH3	28 ± 5

NA: not active

ED₅₀ values are expressed as 'means ± standard deviations'.