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. 2008 Oct 8;8:172. doi: 10.1186/1471-2180-8-172

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Copyright © 2008 Horzempa et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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COG analysis of genes up- or down-regulated by mammalian temperature. COG categories were identified for each significantly up- or down-regulated gene based on the genomic annotation (accession, NC_07880). Specific COG categories were consolidated into general categories as follows: J, K, L, and RNA genes were combined into "Transcription/translation/DNA replication/RNA"; P, C, G, E, F, H, I, and Q were merged into "Transport and metabolism"; categories N and U were combined into "Cellular functions/trafficking/secretion"; and categories R, S, and uncategorized genes were classified as "Unknown". All other COG categories were reported as they were originally assigned.