Table 2.
Association of MDM2 SNP309 genotype and clinicopathological characteristics.
| 309 SNP Genotype | Parameter category n (%) | OR (95% CI) | p | ||||
| All patients (n = 299) | T/T | 118 (39.5) | |||||
| T/G | 141 (47.2) | ||||||
| G/G | 40 (13.4) | ||||||
| Menopausal status (n = 299) |
Pre (n = 70) |
Post (n = 229) |
|||||
| T/T | 32 (45.7) | 86 (37.6) | 0.71 (0.42 – 1.23) | 0.22 | |||
| T/G | 28 (40.0) | 113 (49.3) | 1.46 (0.85 – 2.52) | 0.17 | |||
| G/G | 10 (14.3) | 30 (13.1) | 0.91 (0.42 – 1.96) | 0.78 | |||
| ER status (n = 299) |
Positive (n = 226) |
Negative (n = 71) |
|||||
| T/T | 91 (40.3) | 28 (39.4) | 1.11 (0.643 – 1.94) | 0.38 | |||
| T/G | 108 (47.8) | 31 (43.7) | 1.12 (0.65 – 1.93) | 0.67 | |||
| G/G | 27 (11.9) | 12 (16.9) | 0.65 (0.31 – 1.35) | 0.24 | |||
| Tumour Grade (n = 298) |
DCIS (n = 20) |
1 (n = 47) |
2 (n = 107) |
3 (n = 124) |
|||
| T/T | 5 (25.0) | 18 (38.3) | 42 (39.2) | 53 (42.7) | 1.21 (0.93 – 1.56) | 0.15 | |
| T/G | 15 (75.0) | 25 (53.2) | 53 (49.5) | 48 (38.7) | 0.68 (0.53 – 0.88) | 0.003 | |
| G/G | 0 | 4 (8.5) | 12 (11.2) | 23 (18.5) | 1.64 (1.06 – 2.53) | 0.025 | |
| Nodal status (n = 298) |
Positive (n = 128) |
Negative (n = 170) |
|||||
| T/T | 50 (39.1) | 67 (39.4) | 0.98 (0.62 – 1.58) | 0.95 | |||
| T/G | 53 (41.4) | 88 (51.8) | 0.66 (0.41 – 1.05) | 0.07 | |||
| G/G | 25 (19.5) | 15 (8.8) | 2.51 (1.26 – 4.98) | 0.009 | |||
| NPI (n = 297) |
DCIS (n = 20) |
Good (n = 72) |
Moderate (n = 123) |
Poor (n = 82) |
|||
| T/T | 5 (25.0) | 30 (41.7) | 47 (38.2) | 35 (42.7) | 1.00 (0.85 – 1.19) | 0.95 | |
| T/G | 15 (75.0) | 37 (51.4) | 59 (48.0) | 30 (36.6) | 0.87 (0.73 – 1.03) | 0.11 | |
| G/G | 0 | 5 (6.9) | 17 (13.8) | 17 (20.7) | 1.30 (1.02 – 1.65) | 0.03 | |
| HER-2 status (n = 196) |
Positive (n = 47) |
Negative (n = 149) |
|||||
| T/T | 18 (38.3) | 57 (38.3) | 1.00 (0.51 – 1.97) | 1.00 | |||
| T/G | 19 (40.4) | 73 (49.0) | 0.71 (0.36 – 1.37) | 0.30 | |||
| G/G | 10 (21.3) | 19 (12.8) | 1.85 (0.79 – 4.31) | 0.16 | |||
| PgR Status (n = 294) |
Positive (n = 181) |
Negative (n = 113) |
|||||
| T/T | 68 (37.6) | 48 (42.5) | 0.82 (0.49 – 1.36) | 0.40 | |||
| T/G | 90 (49.7) | 49 (43.4) | 1.29 (0.78 – 2.13) | 0.29 | |||
| G/G | 23 (12.7) | 16 (14.1) | 0.88 (0.42 – 1.88) | 0.72 | |||
Association of MDM2 SNP309 genotype and clinicopathological characteristics. Each genotype was compared to all the other samples. OR = Odds ratio, CI = Confidence interval.