Table 3.
Univariate analyses of clinical recurrence with clinicopathological parameters in 293 patients with PTMC, according to surgical extent
| Baseline characteristics | Patients with total or near-total thyroidectomy (n = 166) | Patients with hemi- or subtotal thyroidectomy (n = 127) | Overall (n = 293) | ||||||
| HR | 95% CI | P | HR | 95% CI | Pa | HR | 95% CI | P | |
| Age at operation | |||||||||
| ≤ 45 yrs | 1.88 | 0.45–7.90 | 0.39 | 3.19 | 0.37–27.3 | 0.29 | 2.28 | 0.71–7.27 | 0.16 |
| > 45 yrs | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - |
| Gender | |||||||||
| Men | 5.92 | 1.41–24.8 | 0.02 | 4.6 | 0.83–25.4 | 0.96 | 5.22 | 1.74–15.6 | 0.003 |
| Women | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - |
| Tumor size | |||||||||
| Per 1 mm increase | 1.21 | 0.82–1.78 | 0.35 | 1.01 | .0.68–1.51 | 0.96 | 1.11 | 0.85–1.45 | 0.45 |
| Multifocality | |||||||||
| Solitary tumor | 1.48 | 0.35–6.19 | 0.59 | 0.25 | 0.05–1.36 | 0.11 | 0.87 | 0.29–2.59 | 0.8 |
| Multifocal tumor | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - |
| Extrathyroid extension | |||||||||
| Absent | 0.5 | 0.12–2.09 | 0.34 | 0.37 | 0.08–1.86 | 0.23 | 0.45 | 0.16–1.31 | 0.14 |
| Present | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - |
| Lymph node metastasis | 0.08 | 0.83 | 0.049 | ||||||
| pNx | 0 | NC | 1 | 1.64 | 0.33–8.14 | 0.54 | 1.62 | 0.39–6.79 | 0.51 |
| pN0 | 0 | NC | 1 | 0 | NC | 0.99 | 0 | NC | 0.99 |
| pN1aa | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - |
| pN1bb | 8.25 | 1.66–40.9 | 0.01 | N/A | 5.25 | 1.60–17.3 | 0.51 | ||
| Bilaterality | |||||||||
| Unilateral tumor | 0.71 | 0.17–2.97 | 0.64 | N/A | 0.81 | 0.23–2.90 | 0.74 | ||
| Bilateral tumor | 1.00 | - | - | 1.00 | - | - | |||
| Remnant ablation | |||||||||
| Not done | 0 | NC | 1 | N/A | N/A | ||||
| Done | 1.00 | - | - | ||||||
a Metastases to level VI lymph nodes (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes), classified as N1a in the 2002 TNM staging.
b Metastases to unilateral, bilateral, or contralateral cervical superior mediastinal lymph nodes, classified as N1b in the 2002 TNM staging.
Percent recurrence rates were given in parentheses; HR, hazard ration; CI, confidence interval; N/A, not applicable; INF, infinite; NC, cannot calculate