Skip to main content
. 2008 Oct 6;5:89. doi: 10.1186/1742-4690-5-89

Figure 4.

Figure 4

Sensitivity of pseudotypes to fusion inhibitors. Pseudotypes were incubated for 1 h. at 37°C with fusion inhibitors T-1249 (A) and T-1249-BR (a peptide that contains amino acid residues conserved in brain but absent in spleen derived Env of one individual) (B), and then the mixture was used to infect HOS-CD4-CCR5 cells. Pseudotypes containing BR, BS, Bv1v3, Bv1v2 and BR(N283T) Env were significantly less sensitive to T-1249 and T-1249-BR than those with SPL and SB Env. Data from a representative experiment repeated at least 4 times with similar results are shown.