Figure 7.

Pseudotype infection of HOS-CD4-CCR5 cells (top) and monocyte-derived macrophages (bottom). Pseudotypes containing wild-type, chimeric and mutant Env that had shown low CD4 dependence and high avidity for CD4, as well as reduced sensitivity to fusion inhibitors and BMS-378806, showed statistically significant greater macrophage tropism than those without low CD4 dependence and less avidity for CD4. Results shown are the mean relative light units (RLU) per second ± standard error of 3 independent experiments (each performed at least in triplicate).