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Carbachol did not synchronize islets pretreated with unequal concentrations of glucose. Islets were incubated with different glucose concentrations (7.5, 11.1, or 15 mM) for 30 min before recording commenced, and then were exposed to saline containing 11.1 mM glucose. As shown in the figure, the islets had different patterns of [Ca2+]i oscillations. The application of 25 μM carbachol still initiated a peak in [Ca2+]i, but then failed to synchronize islet [Ca2+]i signals.
