FIGURE 2.

The TnC-TnI assembly represented as a Markov network (see text). (a) The parent network with system-states (s₀\s₁s₂) as nodes and bi-directional transitions as edges. (b) Reduced models of activation and deactivation showing transition rates k_i, i = 1, 2, 3, Ca²⁺ affinity constants K_j, j = 0, 1, 2, kinetic linkages between activation and deactivation, and degeneracy in k₂ and k₋₂. Dominant (red) are minor (blue) pathways and common portions (green) are shown. Double arrows indicate transitions with the reversible binding of Ca²⁺. For protein isomerizations, single arrows indicate the direction of net probability flux.