TABLE 2.

Thermokinetic parameterization of the opening/closing transition of cardiac TnC-TnI

Parameter	Value
ΔH (kJ/mol)	−33.4
δ‡	10.6
	44.0
ΔS (kJ/mol/K)	−0.110
ΔCp	−7.6
νadj (s−1)	1.8 × 104
νadj,R	1.0 × 1010

For opening: ΔH, net enthalpy change; ΔC_p, heat capacity change; ΔS, net entropy change; δ^‡, enthalpy of activation; and ν_adj = ν exp(σ^‡/R), entropy-adjusted barrier crossing attempt frequency (ν, barrier crossing attempt frequency; σ^‡, entropy of activation). For closing: enthalpy of activation; and ν_adj,R entropy-adjusted barrier crossing attempt frequency.