Skip to main content
. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2008 May 2;1784(9):1342–1346. doi: 10.1016/j.bbapap.2008.04.016

Fig. 3. Inhibition of GNMT by (6S)-5-CH3-THF-mono- (A) and pentaglutamate (B).

Fig. 3

Enzyme activity of liver (closed circles) and recombinant (open circles) GNMTs was measured at 400 µM concentration of AdoMet after pre-incubation with different concentrations of folates. Data are presented as percent of activity of enzymes in the absence of folate against the logarithm of folate concentrations. The activity of GNMT in 1 µM monoglutamate and 0.01 µM pentaglutamate was equal to the activity without folate.