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. 2008 Nov 7;3(11):e3671. doi: 10.1371/journal.pone.0003671

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(a) Classification system used to categorize the copy number of CCL3L1 (low or high) and genotypes of CCR5 (detrimental or nondetrimental) into three (low, moderate and high) risk categories. (b) Conceptual model by which the GRGs might affect epidemiological endpoints. The endpoint Pc has different components, and those that might be influenced by the GRGs are shown in green-colored letters, i.e., Ro, e and f. The model assumptions, parameters and methods are described in Supplementary Online Materials S1 (SOM), section 1 and Table S1. The conceptual model assumes a vaccine that requires the induction of CMI, in part, for protection. Here, the formula of Pc is from studies by Anderson [1] and Blower [2]. ?, indicates possible additional effects associated with CCL3L1-CCR5 GRGs that are unmeasured [53], [63].