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. 2008 Nov 14;4(11):e1000259. doi: 10.1371/journal.pgen.1000259

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Etheridge et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Deconvolution microscopy image showing EGFP-Dvl2 BAC transgene expression in the heart at E9.5 (A). The hearts of E18.5 embryos collected from Dvl2 ^−/−×Dvl3 ^+/− crosses were examined and conotruncal abnormalities were observed in 11/28 Dvl2 ^+/−;Dvl3 ^+/− hearts (B). Whole mount (C,E) and sectioned (D,F) E18.5 Dvl2 ^+/−;Dvl3 ^+/− hearts showing normal morphology (C,D), DORV (E) and TGA (F). Whole mount (G, I, K, M) and sectioned (H, J, L, N) E18.5 Dvl2 ^+/−;Dvl3 ^−/− hearts showing cardiac abnormalities with varying degrees of severity. Three (I,J) appeared similar to Dvl3 ^−/− mutants (G,H), two had a ‘medium’ phenotype, which was worse than Dvl3 ^−/− mutants (K,L) and two had a much worsened phenotype compared to Dvl3 ^−/− mutants with severely altered morphology (M,N).