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Pathogenesis in SCID mice infected intra-nasally with wtVACV or VACV E3L mutants. Groups of five female SCID mice were infected intra-nasally with either wtVACV or the indicated VACV E3L mutants at the indicated doses. Mice were weighed every other day and monitored for 1 month for signs of illness. Percent survival is presented in panel A, and weight loss is presented in panel B. For panel B, lines ending prematurely indicate mortality.
