Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of results
| Virus | IC LD50 (pfu) | IN LD50 (pfu) | SCID pathogenesis | IN protective dose (pfu) | Efficacya |
|---|---|---|---|---|---|
| wt VACV | 102 | 4 × 103 | ++++ | nd | nd |
| VACVE3LA83N | 3 × 104 | 4 × 107 | +++ | 100 | 4 × 105 |
| VACVE3LA7C | 106 to 107 | >107 | ++ | 100–1000 | >104 to 105 |
| VACVE3LA54N | 8 × 106 | >107 | + | 20,000 | >5 × 102 |
| VACVAE3L∷Orf E3L | >107 | >107 | +++ | 100 | >105 |
| VACVAE3L | >106 | >107 | − | 1000 | >104 |
Efficacy is defined as IN LD50/IN protective dose.
