Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Oct 30;14:1974–1982.

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Sequencing analysis of six families with OA1. The mutant GPR143 sequence (left) and corresponding normal sequence (right) are shown for families 1–4. The exact mutation is labeled under each sequence according to the nomenclature recommended by Human Genomic Variation Society (HGVS). Each mutation is marked with an arrow. In family 5, direct sequencing image was obtained by direct sequencing. The long band in Family 5 including exons 2 and 3, represents the large intragenic deletion region, which encompasses about 6,164 bp from g.1103 to g.7266 of GPR143. In family 6, direct sequencing image was obtained by direct sequencing, and the lower long band represents the deletion from g.25985 to g.26546 encompassing exon 8. The location of the six mutations within GPR143 is exhibited at the bottom of the Figure 4. Exons are shown as open boxes numbered 1–9, and thin lines represent introns. The locations of the six mutations found in this study are indicated beside the exons.