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MAT-IIβ ablation induces high levels of apoptosis and necrosis of leukemic cells. A, propidium iodide-stained necrotic cells (%) at 20 μm l-Met. B, propidium iodide-stained necrotic cells (%) at 50 μm l-Met. C, necrotic cells (%) at 6 days in 5–50 μm l-Met. D, annexin-V-stained apoptotic cells (%) at 20 μm l-Met. D, annexin-V stained apoptotic cells (%) at 50 μm l-Met. F, apoptotic cells (%) at 6 days in 5–50 μm l-Met. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001.
