FIG. 1.

Development of INR (▴), serum ALT (37°C) (•), and total bilirubin (□) over time. The detection of HAV- and RVFV-specific IgG, IgM, and HAV RNA is depicted in the upper part. +(st), positive in stool; +(pl), positive in plasma; +(lb), positive in liver biopsy specimen. Shown are levels of ALT (in U/liter [U/l]; reference range, <34 U/liter) and total bilirubin (in mg/dl; reference range, <1 mg/dl) and INR of prothromb in time (0.9 to 1.25), influenced by fresh frozen plasma. The patient died (†) on day 11 (17 days after the onset of symptoms).