TABLE 2.

Diagnosis of IA and its documentation

Patient no.	Criteria for IA according to EORTCa					Date of diagnosisb	Result for the following assay:
	Host factors	Clinical evidence		Microbiological evidence			GMA		RT-PCR
		Major	Minor	Culture	GM in CSF or BAL				LSV		SSV
							No. of positive samples	Date of first positive sample	No. of positive samples	Date of first positive sample	No. of positive samples	Date of first positive sample
1	Yes	C	S, N, P	NP	NP	3/14/2006	2	2/20/2006	2	2/27/2006	0
2	Yes	H	S, N, P	A. fumigatus from BAL	BAL	12/4/2006	3	12/22/2006	1	12/22/2006	1	12/22/2006
3	Yes	H	S, N	Negative	NP	2/12/2006	6	2/12/2006	2	2/12/2006	2	2/12/2006
4	Yes	H	S, N, P	A. fumigatus from BAL	?	1/11/2007	2	1/8/2007	1	1/13/2007	0
5	Yes	H	S, N, P	Negative	NP	2/10/2006	2	2/5/2007	4	1/29/2007	2	2/5/2007
6	Yes	No	N, I	Negative	NP	4/24/2006	9	3/20/2006	5	4/4/2006	3	4/4/2006
7	Yes	No	N, I	Negative	NP	6/1/2006	2	7/3/2006	1	7/3/2006	1	7/3/2006
8	Yes	H, C	S, I, P	Negative	Negative	1/23/2007	2	2/14/2007	4	1/24/2007	1	2/19/2007
9	Yes	H	S, P	Negative	NP	4/11/2006	26	4/3/2006	14	4/3/2006	14	4/3/2006
10	Yes	No	S, I, N, P	Negative	NP	8/17/2006	2	9/6/2006	3	9/4/2006	0
11	Yes	No	S, N	NP	NP	4/27/2006	2	4/25/2006	4	4/19/2006	1	4/25/2006
12	Yes	No	S, I, N, P	Negative	NP	11/16/2006	7	11/8/2006	4	11/8/2006	3	11/8/2006
13	Yes	H	S, I, P	A. fumigatus from BAL	NP	2/24/2007	3	2/19/2007	5	2/19/2007	2	2/21/2007
14	Yes	No	S, P	A. fumigatus from sputum and skin	CSF	1/9/2007	4	12/28/2006	3	1/2/2007	0
15	Yes	H	S	Negative	NP	2/21/2006	5	2/16/2006	4	2/16/2006	3	2/20/2006
16	Yes	No	N, I	Negative	NP	10/10/2006	0		1	10/2/2006	1	10/10/2006
17	Yes	No	N, P	Negative	NP	4/4/2006	1	3/28/2006	1	3/28/2006	1	3/28/2006

^aCriteria are from Table 2 in Ascioglu et al. (2). CSF, cerebrospinal fluid; H, halo sign; C, air-crescent sign or cavity within area of consolidation; S, symptoms of lower respiratory tract infection; I, any new infiltrate not fulfilling major criteria; N, multiple nodular lesions in the lung, P, pleural effusion; NP, not performed.

^bDefined as the first day on which clinical and/or microbiological criteria were met.