TABLE 1.
Discriminatory power of the typing methods in M. tuberculosis Beijing genotype strains from Russia, study set 1 (48 strains with mainly different IS6110-RFLP profiles)
| Methoda | No. of types | No. of unique isolates | No. of clustered isolates | No. of clusters | Range of cluster sizes (no. of strains) | HGI |
|---|---|---|---|---|---|---|
| IS6110-RFLP | 44 | 40 | 8 | 4 | 2 | 0.996 |
| 12-MIRU | 12 | 7 | 41 | 5 | 2-23 | 0.723 |
| 15-VNTR | 23 | 15 | 33 | 8 | 2-13 | 0.905 |
| 24-VNTR | 24 | 16 | 32 | 8 | 2-13 | 0.906 |
| 15 VNTR loci plus 3 HV loci | 34 | 25 | 23 | 9 | 2-7 | 0.974 |
| Reduced scheme A (11 loci) | 34 | 25 | 23 | 9 | 2-7 | 0.974 |
| Reduced scheme B (7 loci) | 29 | 18 | 30 | 11 | 2-8 | 0.963 |
| Reduced scheme C (5 loci) | 25 | 14 | 34 | 11 | 2-10 | 0.941 |
a
The 12-MIRU is from Supply et al. (29); 15- and 24-MIRUs are from Supply et al. (33); the three HV loci are from Iwamoto et al. (11). Reduced scheme A loci (HGI > 0.1) included QUB-11b, Mtub21, QUB-26, MIRU26, ETR-A, MIRU40, MIRU31, MIRU20, QUB-3232, VNTR-3820, and VNTR-4120. Reduced scheme B loci (HGI > 0.1; number of alleles, >3) included QUB-11b, Mtub21, QUB-26, MIRU26, QUB-3232, VNTR-3820, and VNTR-4120. Reduced scheme C loci (HGI > 0.5 or >3 alleles) included QUB-26, MIRU26, QUB-3232, VNTR-3820, and VNTR-4120.