FIG. 1.

FolT and ThiT proteins and the genomic context of folT and thiT genes. (A) Deduced protein sequence of L. casei FolT. Predicted transmembrane domains are colored blue. (B) Clustering of genes encoding FolT homologs with folC (folylpolyglutamate synthase-dihydrofolate synthase) in the genomes of two Firmicutes. Arrows indicate transcriptional direction. (C) Aligned sequences of L. casei ThiT and Bacillus subtilis YuaJ. Predicted transmembrane domains of ThiT are colored blue. Symbols beneath residues indicate identity (*) and similarity (:). (D) Clustering of genes encoding ThiT homologs with thiN (thiamine pyrophosphorylase) in genomes of the Firmicutes Carboxydothermus hydrogenoformans and Halothermothrix orenii.