. Author manuscript; available in PMC: 2008 Oct 31.

Published in final edited form as: Neurochem Res. 2007 Mar 7;32(4-5):931–946. doi: 10.1007/s11064-006-9268-7

Table 2.

Summary of the physiological properties of the three HIF prolyl 4-hydroxylases indicating their ability to modify Pro402/564 (designated position in human HIF), intracellular localization (N, nuclear; C, cytosolic), ability to mediate HIF-1 stability as determined by RNA interference, induction of hydroxylase mRNA expression in response to hypoxia, and tissue expression patterns [26]

Gene	Size kDa	Substrate		Localization	RNAi	Hypoxia induction	Tissue distribution
		p402	p564			Hypoxia induction
EGLN1/HPH-2/PHD2	46	+	+	C/ > N	+ + +	+	liver = heart > brain = kidney > lung
EGLN2/HPH-3/PHD1	43.6	+	+	N	+	−	Testis > liver > kidney = heart = brain
EGLN3/HPH-1/PHD3	27.3	−	+	C/N	−	+	Heart > liver > brain > kidney > lung