Figure 4.
Zinc block of currents from transfections with GABAA receptor subunits and tandems. A, Current traces from 200 ms 1 mm GABA pulses (black) superimposed with currents from the same patch exposed to a coapplication of 1 mm GABA plus 30 μm ZnCl2 (gray) after equilibration in control solution plus 30 μm ZnCl2. B, Histograms for percentage of peak current blocked by Zn2+ for 200 ms GABA pulses. α1β2γ2S 1:1:10, αβtan+γ2S, αβtan+γ2L 1:1:10, and αβtan+γ2L transfections (black bars) are significantly different (p < 0.001) from α1β2 and αβtan+α transfections (open bars). Data are mean ± SD (to show error) for 4–17 patches for each condition.