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. Author manuscript; available in PMC: 2008 Oct 31.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Jun 3;326(3):871–878. doi: 10.1124/jpet.108.137919

Figure 6.

Figure 6

Activation of PKC with the phorbol ester PMA (300 nM) increases peak calcium current and current density in both PC12-H3 (Panel A) and PC12-H3/β-ARK1 cells (Panel B). In PC12-H3 cells, incubation with imetit (100 nM) significantly reduces peak calcium current, an effect inhibited by CBP (50 nM). Notably, the imetit-induced calcium current reduction in PC12-H3 cells is not present in PC12-H3/β-ARK1 cells. Bars represent means (± SEM; n = 20; *p < 0.05 and **p < 0.01 by ANOVA followed by post hoc Dunnett's test).