Table 1.
Downregulated genes in the ATRX-null forebrain at E13.5 and P0.5.
| Chromosome | |||||
| Gene | Description | Mouse | Human | Fold Change | Genbank |
| E13.5 Downregulated Genes | |||||
| IMAGE:354942 | Similar to dehydrogenase/reductase (SDR family) X chromosome (Dhrsxy)1 | 4 | X/Y PAR | -4.81 | W45978 |
| Csf2ra | Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 19 | X/Y PAR | -3.05 | BM941868 |
| Vit | Vitrin | 17 | 2 | -2.74 | AF454755 |
| Shox2 | Short stature homeobox 2 | 3 | X/Y PAR | -2.73 | AV332957 |
| Tcf7l2 | Transcription factor 7-like 2, T-cell specific, HMG-box | 19 | 10 | -2.72 | BB175494 |
| Gbx2 | Gastrulation brain homeobox 2 | 1 | 2 | -2.55 | L39770 |
| IMAGE:3326212 | Similar to Arylsulfatase E (Arse)1 | - | X/Y | -2.21 | BE457721 |
| Syt13 | Synaptotagmin 13 | 2 | 11 | -2.19 | BB244585 |
| Cd99 | CD99 antigen | 4 | X/Y PAR | -2.09 | AK004342 |
| Nxph1 | Neurexophilin 1 | 6 | 7 | -1.92 | BB274960 |
| Neurod4 | Neurogenic differentiation 4 | 10 | 12 | -1.86 | NM_007501 |
| Nxph2 | Neurexophilin 2 | 2 | 2 | -1.86 | BB169128 |
| Peg10 | Paternally expressed 10 | 6 | 7 | -1.86 | BG076799 |
| RIKEN:1810009N02 | Similar to Asmtl (acetylserotonin O-methyltransferase-like)1 | - | X/Y PAR | -1.81 | AK007409 |
| Wif1 | Wnt inhibitory factor 1 | 10 | 12 | -1.81 | BC004048 |
| P0.5 Downregulated Genes | |||||
| Csf2ra | Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 19 | X/Y PAR | -7.14 | BM941868 |
| Nr4a2 | Nuclear receptor subfamily 4, group A, member 2 | 2 | 2 | -3.33 | NM_013613 |
| IMAGE:354942 | Similar to Dhrsxy (dehydrogenase/reductase (SDR family) X chromosome1 | 4 | X/Y PAR | -3.33 | W45978 |
| IMAGE:5656844 | Unknown EST | - | - | -2.86 | BI320076 |
| Met | Met proto-oncogene | 6 | 7 | -2.78 | BG060788 |
| Cd99 | CD99 antigen | 4 | X/Y PAR | -2.22 | AK004342 |
| Dsc3 | Desmocollin 3 | 18 | 18 | -2.22 | NM_007882 |
| Mbp | Myelin basic protein | 18 | 18 | -2.17 | AI323506 |
| Cbln4 | Cerebellin 4 precursor protein | 2 | 20 | -2.08 | AV343573 |
| EST | Unknown EST | - | - | -2.08 | BI202412 |
| Trpc4 | Tansient receptor potential cation channel, subfamily C, member 4 | 3 | 13 | -2.04 | BB271442 |
| RIKEN:1810009N02 | Similar to Asmtl (acetylserotonin O-methyltransferase-like)1 | - | X/Y PAR | -2.00 | AK007409 |
1By BLASTn
cRNA was generated from total forebrain RNA from three pairs of littermate-matched ATRX-null and wild type forebrain tissue and hybridized to an Affymetrix Mouse Genome 430 2.0 Array. Data was analyzed using GeneSpring. Probesets were filtered by fold change (1.8 fold at P0.5, 2 fold at E13.5) and confidence, P < 0.05, and duplicate genes were removed. Ancestral PAR genes are highlighted in grey.