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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Epilepsia. 2008 May 29;49(10):1749–1758. doi: 10.1111/j.1528-1167.2008.01687.x

Figure 4.

Figure 4

SNARE Effectors Tomosyn and SV2 Show Kindling- and LEV-Dependent Changes in Expression Levels. Rats were injected i.p. with LEV (UCB L059, 108mg/kg, green squares) or an inactive enantiomer of LEV (UCB L060, 108mg/kg, orange squares) 1 hr prior to daily amygdalar kindling-inducing electrical stimulation. At the indicated times, hippocampal tissue was prepared and synaptosomal proteins were probed for α-SNAP, NSF, Tomosyn, and SV2 (as indicated) by quantitative western blotting and compared and “Total Relative Value” was calculated as described in Methods. Each square represents the mean ±SEM of protein determinations from 4−10 animals; * indicates p < 0.05 for the indicated pairs. For SV2 determinations at Day 12, n=5 for both LEV and enantiomer; at Day 15, n=7 for LEV and n=8 for enantiomer.