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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Epilepsia. 2008 May 21;49(10):1777–1786. doi: 10.1111/j.1528-1167.2008.01674.x

Fig. 5. Afterdischarge properties and seizure responses to test stimulation 24 hours after rapid kindling.

Fig. 5

A. Afterdischarge (AD) properties are expressed as percent of respective values prior to kindling for the same animals. Behavioral seizure severity is presented as Mean ± SEM. Asterisk – p < 0.05 vs. respective values before kindling (paired Student t-test); dagger- p < 0.05 vs. Vehicle treated age-matched rats (Student t-test for afterdischarge properties; Mann-Whitney test for behavioral seizure score). B. Examples of electrographic responses obtained 24 hours after rapid kindling from P21 rats which had been treated with either vehicle or retigabine (RTG) prior to kindling procedure. Note that in the vehicle – treated animal, afterdischarge developed in response to a lower-current stimulation (indicated on the left side of each tracing), and that the duration of afterdischarge was longer, as compared to the retigabine – treated rat (afterdischarges are outlined by dashed rectangles). Furthermore, both afterdischarge threshold and duration in the retigabine- treated animal are similar to those observed in retigabine – free animals prior to kindling (compare with the top tracing in Fig. 3 B).