Table II.

Association of selected variables with risk of HPV16-associated oral cancer

Variables	HPV16 status	Cases (n = 326)		Controls (n = 349)		Adjusted OR (95% CI)a
		No.	%	No.	%
All subjects	−	226	69.3	306	87.7	1.00
	+	100	30.7	43	12.3	3.42 (2.28–5.13)
p53 genotypes
Arg/Arg	−	135	73.8	156	86.2	1.00
	+	48	26.2	25	13.8	2.65 (1.52–4.63)
Arg/Pro + Pro/Pro	−	91	63.6	150	89.3	1.00
	+	52	36.4	18	10.7	5.00 (2.72–9.21)
p73 genotypes
GC/GC	−	136	69.7	187	87.4	1.00
	+	59	30.3	27	12.6	3.20 (1.91–5.36)
GC/AT + AT/AT	−	90	68.7	119	88.1	1.00
	+	41	31.3	16	11.9	3.83 (1.98–7.41)
Age (years)
≤55	−	98	60.5	152	88.4	1.00
	+	64	39.5	20	11.6	4.93 (2.77–8.77)
>55	−	128	78.0	154	87.0	1.00
	+	36	22.0	23	13.0	2.16 (1.18–3.93)
Sex
Male	−	159	65.7	239	87.9	1.00
	+	83	34.3	33	12.1	3.96 (2.50–6.29)
Female	−	67	79.8	67	87.0	1.00
	+	17	20.2	10	13.0	1.60 (0.67–3.84)
Smoking
Never	−	60	60.6	97	90.7	1.00
	+	39	39.4	10	9.3	8.20 (3.66–18.4)
Ever	−	166	73.1	209	86.4	1.00
	+	61	26.9	33	13.6	2.48 (1.53–4.01)
Drinking
Never	−	51	67.1	84	90.3	1.00
	+	25	32.9	9	9.7	6.22 (2.45–15.8)
Ever	−	175	70.0	222	86.7	1.00
	+	75	30.0	34	13.3	2.89 (1.83–4.59)

^aHPV positive versus HPV negative in each stratum; ORs were adjusted for age, sex, smoking and drinking status in logistic regression models.