Table IV.
Stratification of risk of oral cancer in never-smokers and ever-smokers by combined p53 and p73 genotypes and HPV16 exposure
| Smoking status and risk groupa | HPV16 status | Cases (n = 326) |
Controls (n = 349) |
Crude OR (95% CI) | Adjusted OR (95% CI)b | ||
| No. | % | No. | % | ||||
| Never-smokers | (n = 99) | (n = 107) | |||||
| Low-risk group | − | 22 | 22.2 | 26 | 24.3 | 1.00 | 1.00 |
| + | 13 | 13.1 | 5 | 4.7 | 3.07 (0.95–9.97) | 3.55 (1.04–12.1) | |
| Medium-risk group | − | 29 | 29.3 | 52 | 48.6 | 0.66 (0.32–1.36) | 0.59 (0.28–1.27) |
| + | 19 | 19.2 | 4 | 3.7 | 5.61 (1.66–19.0) | 6.99 (2.00–24.4) | |
| High-risk group | − | 9 | 9.1 | 19 | 17.8 | 0.56 (0.21–1.49) | 0.50 (0.18–1.37) |
| + | 7 | 7.1 | 1 | 0.9 | 8.27 (0.94–72.5) | 11.3 (1.22–106.0) | |
| Ever-smokers | (n = 227) | (n = 242) | |||||
| Low-risk group | − | 59 | 26.0 | 66 | 27.3 | 1.00 | 1.00 |
| + | 18 | 7.9 | 12 | 4.9 | 1.68 (0.75–3.77) | 1.85 (0.81–4.23) | |
| Medium-risk group | − | 80 | 35.2 | 107 | 44.2 | 0.84 (0.53–1.32) | 0.76 (0.48–1.22) |
| + | 26 | 11.5 | 14 | 5.8 | 2.08 (0.99–4.35) | 1.89 (0.87–4.04) | |
| High-risk group | − | 27 | 11.9 | 36 | 14.9 | 0.84 (0.46–1.54) | 0.78 (0.42–1.46) |
| + | 17 | 7.5 | 7 | 2.9 | 2.72 (1.05–7.00) | 2.88 (1.10–7.56) | |
a
Low-risk group: individuals with p53 Arg/Arg and p73 GC/GC genotypes; medium-risk group: individuals with p53 Arg/Arg and p73 AT carriers or p53 Pro carriers and p73 GC/GC and high-risk group: individuals with p53 Pro carriers and p73 AT carriers.
b
ORs were adjusted for age, sex, smoking and drinking status in logistic regression models.