FIGURE 2.
Activated B cells express LLT1. A, Many immortalized B cell lines express LLT1. B, Microarray expression data reveal that B cells treated with CpG, but not resting or memory B cells, express LLT1. Quantitative RT-PCR confirms that CpG induces LLT1 expression in B cells. C, Western blot analysis of purified B cells demonstrates that activation through CD40, IgM, or TLR9 is sufficient to induce LLT1 protein in sorted B cells. D, CpG DNA, but not other TLR stimuli, induces LLT1 protein on the surface of B cells.