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TBPB is an allosteric agonist of M1 receptors in recombinant systems. TBPB (■; EC50 of 158 ± 21 nm) and carbachol (▴; EC50 of 28.6 ± 2.2 nm) elicit a robust response in CHO-K1 cells expressing WT rM1. Data are mean ± SEM of three to six independent experiments each performed in quadruplicate.
