Figure 7.

TBPB had no effects on evoked EPSCs and IPSCs in CA1 hippocampal pyramidal cells. A, Average traces of EPSCs or IPSCs before application of TBPB or CCh (control), during application of TBPB (10 μm for EPSCs; 3 μm for IPSCs) or CCh (100 μm) from four different cells. TBPB had no effect on the amplitudes of evoked EPSCs (97.4 ± 4.0% of control; n = 5; p > 0.5) or IPSCs (106.5 ± 3.3% of control; n = 4; p > 0.1, Wilcoxon's matched-pair test) in hippocampal pyramidal cells. In parallel studies, CCh induced robust inhibition of EPSC and IPSC amplitudes (16.5 ± 4.0% of control, n = 5 and 15.4 ± 3.1%, n = 5, respectively; Wilcoxon's matched-pair test). B, Bar graph summarizes the effect of TBPB or CCh on EPSC and IPSC amplitude. All data represent mean ± SEM of five to six cells.