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. Author manuscript; available in PMC: 2008 Nov 2.
Published in final edited form as: Drug Metab Dispos. 2008 Jun 19;36(11):2151–2155. doi: 10.1124/dmd.108.022061

Figure 3.

Figure 3

PCA of 21 KI values using 5 probe substrates for CYP2C9. a,b) PCA showing relationships between probe substrates for allelic variant CYP2C9.1 and .3 respectively. Tolbutamide, phenytoin and diclofenac form an apparent cluster for .1, but all five substrates are more evenly dispersed for .3. c,d) PCA of transposed data sets, showing the relative positions of inhibitors in functional space for CYP2C9 allelic variants .1 and .3 respectively. The recovered functional mapping is quite similar for both variants: quinine and thiobendazole are distinct outliers in both cases.