Table 2.

K_I values (in μM) calculated for 21 inhibitors and 5 probe substrates of CYP2C9. Taken with permission from Table 1 of Kumar et al. (2006).

	CYP2C9.1					CYP2C9.3
	Flurbiprofen	Warfarin	Phenytoin	Tolbutamide	Diclofenac	Flurbiprofen	Warfarin	Phenytoin	Tolbutamide	Diclofenac
Amiodarone	2.1	2.99	4.03	0.69	1.89	3.64	1.66	1.87	0.81	2.1
Benzbromarone	0.004	0.001	0.04	0.02	0.01	1.54	0.01	0.71	0.03	0.04
Clozapine	4.13	3.46	12.88	11	11.43	10.49	2.8	5.07	5.92	8.04
Fluvoxamine	0.63	0.58	2.46	2.74	4.12	4.19	0.67	2.37	1.57	2.53
Gemfibrozil	12.43	0.79	2.38	2.83	3.64	14.33	1.65	4.95	7.21	14.41
(S)-Ibuprofen	4.27	3.06	4.02	3.95	4.46	9.78	3.15	5.5	14.03	14.68
Indomethacin	53.41	0.66	15.76	14.24	14.47	38.74	5.04	12.66	16.87	25.62
Ketoconazole	0.38	0.08	1.81	1.79	1.52	1.51	0.08	0.69	0.7	0.79
Mibefradil	11.1	1.04	6.75	6.63	13.79	13.08	1.8	6.9	6.9	14.3
Miconazole	0.03	0.01	0.11	0.05	0.04	0.1	0.02	0.12	0.06	0.07
α-Naphthoflavone	0.78	0.29	0.75	0.34	0.41	1.13	0.18	0.39	0.24	0.44
Nicardipine	0.07	0.01	0.33	0.03	0.03	0.29	0.01	0.02	0.02	0.02
Nifedipine	1.14	0.34	1.35	0.84	0.57	1.53	0.28	0.61	0.28	1.18
Omeprazole	5.33	0.64	2.16	0.92	0.41	16.24	0.9	1.6	1.46	0.3
Progesterone	1.72	1.41	4.3	4.01	5.2	11.03	1.97	3.27	2.58	7.91
Quercetin	1.18	0.25	0.27	0.14	0.13	0.25	0.11	0.29	0.08	0.13
Quinine	3.45	19.8	85.53	76.35	100	21.2	18.89	39.68	86.52	96.7
Sulfamethizole	17.9	2.22	13.08	7.17	14.69	35.04	3.87	24.74	25.93	31.86
Sulfaphenazole	0.06	0.12	0.23	0.22	0.15	0.72	0.15	0.39	0.33	0.36
Tamoxifen	3.44	0.66	3.77	3.32	4.67	9.77	0.58	6.69	2.72	8.36
Thiobendazole	>100	17.22	36.21	33.09	41.08	100	11.02	26.92	24.54	69.85