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. 2006 Jun 20;11(13):661–668. doi: 10.1016/j.drudis.2006.05.002

Figure 1.

Figure 1

Small-molecule microarray. Chemical compounds synthesized with the same linking functional group are arrayed and covalently immobilized on the surface of microarray chips using a standard microarrayer. Biological targets in cell lysates or in purified forms are added to the chips, this is followed by several washing steps to eliminate non-specific and weak binding. The compounds that bind to the target with high affinity are then identified by immunoassays (the chemical structures shown in all figures are for illustration purposes only).