Table 2.

Chemical microarray platform comparisons

		Small-molecule microarray	Fragment chemical microarray	Dry chemical microarray	Solution-phase chemical microarray
Chemical library		Specific synthesis	Specific synthesis	Any library	Any library
Assays	Protein binder	Immunoassay detection	Label-free surface plasmon resonance (SPR) detection	ELISA, isotopic	ELISA, isotopic, time-resolved fluorescence
	Protein–protein interrupter	Difficult to perform	Difficult to perform	Difficult to perform	ELISA, isotopic, fluorescence labeling, time-resolved fluorescence
	Enzyme inhibitor	Difficult to perform	Difficult to perform	Easy to use; low density, but the resolubilization of compounds might affect reaction kinetics.	Easy to use, high-density array, homogeneous and heterogeneous assays, time dependent and endpoint assays.
Data analysis		DNA microarray software compatible	Specifically designed	Spot finder compatible	DNA microarray software compatible