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. 2006 Jun 20;11(13):661–668. doi: 10.1016/j.drudis.2006.05.002

Table 2.

Chemical microarray platform comparisons

Small-molecule microarray Fragment chemical microarray Dry chemical microarray Solution-phase chemical microarray
Chemical library Specific synthesis Specific synthesis Any library Any library
Assays Protein binder Immunoassay detection Label-free surface plasmon resonance (SPR) detection ELISA, isotopic ELISA, isotopic, time-resolved fluorescence
Protein–protein interrupter Difficult to perform Difficult to perform Difficult to perform ELISA, isotopic, fluorescence labeling, time-resolved fluorescence
Enzyme inhibitor Difficult to perform Difficult to perform Easy to use; low density, but the resolubilization of compounds might affect reaction kinetics. Easy to use, high-density array, homogeneous and heterogeneous assays, time dependent and endpoint assays.
Data analysis DNA microarray software compatible Specifically designed Spot finder compatible DNA microarray software compatible