Figure 5. Roles of TLR(s), MyD88 and IL-17 in chitin-induced acute inflammation.

TLR, MyD88 and IL-17 sufficient (+/+; +) and deficient (−/−; −) mice were treated with intranasal chitin (solid bars, 25 μg) or vehicle controls (hatched bars). Six hours later the animals were sacrificed, BAL was undertaken and lung sections were obtained. The effects of these treatments on differential BAL cell recovery (A, C) and lung histology (H & E staining) (B) were evaluated. * p < 0.05, ** p < 0.01, *** p < 0.001.