Figure 1.

Dose-dependent telomere shortening in mammalian cells exposed to increasing concentrations of 3AB. Telomere length was measured by Q-FISH and resulting values were expressed as percentage of the corresponding control. HeLaS3 and COM3 hamster cells were treated with concentrations of 3AB as indicated for 1 week. Both show a dose-dependent decrease in telomere signal intensity, with ∼85% and 75% of control level, respectively, at the highest concentration of the inhibitor. Squares, HeLaS3; triangles, COM3; *P < 0.05, ^**P < 0.01, compared to control.