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. 2008 Oct 2;36(19):6269–6283. doi: 10.1093/nar/gkn636

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Human apoptosis and genome-stability gene network. (A) Graph of interactions among genes involved in apoptosis and DNA repair pathways, as previously characterized in Castro et al. (19). Different pathways are represented in different colors. Network nodes with more than one color represent genes participating in more than one pathway. Gene IDs of each pathway are provided in Supplementary Table S1. (B) Magnification of TP53 gene position of in the network topology. It highlights the functional overlap of TP53, linking apoptosis to several genome-stability components. (C) Venn diagram showing the distribution of links between apoptosis and genome-stability pathways. The overlapped area corresponds to those links connecting both systems. The large number of associations among NER, MMR and chromosome-stability components is designed as ρ module.