Table 1.

Allelic distribution of CAN genes placed in ρ module according to XP mutation database (Panel A). Sample representativeness compared to a second databases (Panel B)

Panel A	Number of Genotypes (%)a			Total genotypes	(Panel B) Entriesb
CAN gene	null/non-null	non-null/non-null	null/null		XP database	HGMD
ERCC2	20 (43.5)	26 (56.5)	0 (0.0)	46	76c	48
ERCC3	3 (60.0)	2 (40.0)	0 (0.0)	5	8	11
ERCC4	0 (0.0)	7 (100.0)	0 (0.0)	7	18d	17
ERCC5	0 (0.0)	5 (100.0)	0 (0.0)	5	10	12
XPA	6 (6.0)	94 (94.0)	0 (0.0)	100	128e	25
XPC	0 (0.0)	13 (100.0)	0 (0.0)	13	28f	42
DDB2	0 (0.0)	5 (100.0)	0 (0.0)	5	8g	8
Σ	29 (16.0)	153 (84.1)	0 (0.0)	182	276	163

^aData obtained from XP mutations database (http://www.xpmutations.org) is compiled according to the absence (null) or presence (non-null) of CAN gene alleles. Null/non-null genotypes are only heterozygous, while non-null/non-null genotypes include heterozygous and homozygous.

^bThe number of allelic records present in XP mutations database is compared to a second human inherited mutation database [Human gene Mutation Database — HGMD (49)] in order to attest the sample representativeness.

^cOne allele is duplicated in the database (the XP1BR entry).

^dThree alleles have no mutation data (XP80TO, XP81TO and XP89TO entries).

^eOne allele had no zygosity information (XP10OS entry).

^fFour alleles have no zygosity information (XP6BR, XP4BR, XP3BE and XP22BE entries). Polymorphisms are not considered in the analyses.

^gOne allele is duplicated (XP25PV entry).