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. Author manuscript; available in PMC: 2008 Nov 3.
Published in final edited form as: J Immunol. 2008 Jun 15;180(12):8378–8385. doi: 10.4049/jimmunol.180.12.8378

FIGURE 3.

FIGURE 3

Exogenous TG2 accelerates S100A11-induced type X collagen expression in cultured chondrocytes and cartilage in organ culture. A, After 3 days in culture that immediately followed isolation, mouse chondrocytes were treated with 100 ng/ml S100A11 with or without 100 ng/ml TG2 K173L. SDS-PAGE and Western blotting on cell lysates were performed for type X collagen after 2 days in culture. As a control, the effects on expression of type X collagen of the catalytically active but GTP-binding site functional mutant TG2 K173L were examined. B, Mouse femoral head cartilage was treated as in A. Frozen sections were examined by immunohistochemistry for type X collagen as described in Materials and Methods. Data representative of five different mouse donors.