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OTT-MAL interferes with MAL via the leucine zipper dimerization domain. (A) HeLa cells were cotransfected with the SRF reporter, MAL (0.4 μg), and various amounts (0.4, 0.6, and 1 μg) of OTT-MAL. (B) Cotransfection of HeLa cells with MAL (0.2 μg) and various amounts of OTT-MAL ΔLZ or OTT-MAL YY. Luciferase was measured as before. Shown is the mean luciferase activity of duplicates (error bars indicate the half range).
